Traumatic Brain Injury (TBI) has been getting a great deal of attention recently due to vets, NFL, etc, and the DOD identified creatine as a nutrient of interest for TBI over a decade ago for military populations yet little follow up far as I know. Here’s a recent study looking at creatine and TBI in adolescents, and suggest that creatine is very neuro protective with both acute (TBI) and chronic injury. Taken alone, this study is not impressing being a Open Label/Pilot Study, but when added to the growing lit showing the various brain related benefits of creatine, it’s more creatine win in my view:
There has been an enormous focus on the discovery and development of neuroprotective agents that might have clinical relevance after traumatic brain injury (TBI). Based on experimental facts, we studied administration of creatine to patients with TBI.
A prospective, randomized, comparative, open-labeled pilot study of the possible neuroprotective effect of creatine was performed on 39 children and adolescents, aged between 1 to 18 years old, with TBI. The creatine was administered for 6 months, at a dose of 0.4 gr/kg in an oral suspension form every day. For categorical variables, we used the χ2 test to identify differences between controls and cases. Statistical significance was defined as a p value <0.05 and not statistically significant if p value >0.1.
The administration of creatine to children with TBI improved results in several parameters, including duration of post-traumatic amnesia (PTA), duration of intubation, intensive care unit (ICU) stay, disability, good recovery, self care, communication, locomotion, sociability, personality/behavior and neurophysical, and cognitive function. Significant improvement was recorded in the categories of Cognitive (p < 0.001), personality/behavior (p < 0.001), Self Care (p = 0.029), and communication (p = 0.018) aspects in all patients. No side effects were seen because of creatine administration.
Conclusion: Preliminary data suggest that the administration of creatine may be beneficial to patients with traumatic brain injury.