This is an important study as it finds stimulants in pre workout type supplements – currently all the rage in the marketplace – can range significantly over time for the same product, up to 266%! When you combine various stimulants – many of which are listed in the abstract below – it can be potentially dangerous. Manufacturers of such products need to do a far better job of their quality control. Before anyone comments the FDA needs to regulate supplements, I’d recommend reading my article HERE on the total failure of FDA “regulated” drugs and the massive (yet never mentioned in the media…) quality control failures of pharma.
Do “Muscle Building Supplements” increase the risk of testicular cancer? I cover that in this vid!
Muscle-building supplement use and increased risk of testicular germ cell cancer in men from Connecticut and Massachusetts
British Journal of Cancer 112, 1247-1250 (31 March 2015)
Krill oil is becoming increasingly popular, and many people use it as an alternative to fish oil, since both provide the long-chain “marine” omega-3 fatty acids EPA and DHA.
In addition, krill oil has some unique properties, and marketing claims about krill oil’s purported superiority over fish oil abound, centering on the following:
- Krill oil provides some of the EPA and DHA in phospholipid form, which has been suggested to be absorbed more effectively.
- Krill oil contains astaxanthin, a carotenoid with health promoting effects.
- Krill oil contains the essential nutrient choline.
- There are supposedly fewer contaminants in krill oil than fish oil.
- Krill oil supposedly does not cause any fishy burping or other gastro-intestinal side effects.
In this article I will summarize the research on each of these points, and critically evaluate the related marketing claims…
By Monica Mollica & Will Brink
As seen in The Life Extension Magazine May 2014 issue © 2014
Lactoferrin has been experiencing an increased interest by researchers and medical professionals, and rightly so: It’s shown an astounding array of potential benefits to human health and disease prevention. The wide range of potential health and disease fighting properties of lactoferrin are covered extensively in two prior articles “The Bioactive Peptide that Fights Disease” and a later update outlining recent research findings with additional research found . This article shows a recently discovered benefit of this unique peptide that were quite unexpected.
What Is Lactoferrin?
In a nut shell, Lactoferrin is a multi-functional peptide, derived from whey protein; in bovine milk it’s present at approximately 0.5-1.5% of total whey proteins 1, and 0.1 g/liter 2. In addition to its known anti-bacterial 3, anti-viral 4), immune strengthening 5, antioxidant 6, 7, anti-inflammatory 7 and cancer-preventive potential 8, recent studies have discovered novel targets of lactoferrin that can help with fat loss and improve insulin sensitivity and glucose control, which are also essential components to weight loss and overall health.
Lactoferrin for fat loss
A role for lactoferrin in reducing adiposity was first discovered in fat cell culture studies. It was found that lactoferrin specifically inhibits fat accumulation in fat cells, as well as formation of new fat cells (a process called adipogenesis) 9, 10.
Yet another potential benefit of creatine may be improving the effects of SSRIs. There’s many potential health benefits of creatine – for both brain and body – people are unaware of and can read up on via an article I wrote in Life Extension Magazine HERE and here on BrinkZone from vids, articles, free report.
Now, it’s possible, it only works on women and or, only works with this particular SSRI and or only works with MDD. However, knowing that creatine improves brain metabolism in general and has other neuro-protective effects (see recent article linked for more information on that), it’s very unlikely it’s limited to women and or this particular SSRI in my opinion, but one should keep those possible limitation i mind until data shows otherwise. Good science dictates I make sure you’re at least aware of that possible limitation until additional studies done.
I have said this before, and I’ll say it again: Creatine (as monohydrate!) is one of the few supplements I would take and recommended if I didn’t exercise at all.
BTW: The dose of creatine was 3 g/day for the first week and 5 g/day for another 7 weeks.
A Randomized, Double-Blind Placebo-Controlled Trial of Oral Creatine Monohydrate Augmentation for Enhanced Response to a Selective Serotonin Reuptake Inhibitor in Women With Major Depressive Disorder
A key hallmark of aging is a progressive loss of muscle mass, which occurs independently of health status. Exercise and nutrition are the two main anabolic stimuli for muscle growth and its maintenance throughout the life course.[2-11]
It is clear that maintaining high physical activity and exercise levels throughout ones lifespan reduces aging related loss of muscle mass and function, compared with living a sedentary life.[12-19] However, even active older adults and master elite athletes still experience some loss of muscle and physical performance with advancing age.[8, 13, 20]
When it comes to nutrition, high protein intake [2, 3, 10, 21] and creatine supplementation [4-8, 22] are two of the best documented interventions, which together with resistance exercise training, result in greater increases muscle mass and strength in both young [21-23] and older people [2-8, 10], and prevent its loss with aging. Here I will present the relatively unknown effects of fish oil (most well-known for its cardiovascular health promoting effects) on muscle growth (anabolism) and its possible contribution to prevention of aging related loss of muscle mass and function…
I recently published a review paper with Dr. Kyle Hoedebecke examining nutritional supplement in a military setting. Many are unaware that certain nutritional supplements may be of considerable benefits to war fighters. Dr. Hoedebecke and I also had an LTE in the The Journal Of Special Operations Medicine (JSOM) on a similar topic not long ago. Below is the abstract from our recent review with link to the full paper.
The Soldiers of America’s military endure numerous physical and mental challenges that demand strict physical fitness regimens, extreme mental agility, and a perpetual readiness to deploy at a moment’s notice. The chronicity of these stressors has the potential to dramatically reduce performance – both directly and indirectly. Because of this risk, many Soldiers turn to nutritional supplements with hopes of optimizing performance. Increasing amounts of research have demonstrated that various supplements may enhance overall physical prowess, health, and offer quicker recovery in the face of corporal or psychological extremes. Most individuals, including many medical and nutrition professionals, possess only an elementary comprehension of nutritional supplements and their effect on Soldiers in training or combat environments. Nevertheless, a grasp of these details is required for safety and optimal benefits. Various compounds have been evaluated – to include evidence within the military setting – and found to augment endurance, increase cognitive function, decrease knee pain, or offer hearing or lung protection in the face of high-energy impulses. These efficacious outcomes may serve to augment the health and longevity of these Soldiers; however, continued research is needed for efficacy and long-term safety within specific environments.
Full Paper HERE
Indexed on PubMed HERE
Some of the most popular supplements today are the so called pre-workout nitric oxide (NO) boosters [1, 2]. These contain a panoply of ingredients, but one the main ones is arginine. The rationale goes that L-arginine is a precursor to nitric oxide (NO) and NO is a potent vasodilator [3, 4] Theoretically this would increase blood flow and nutrient/oxygen delivery to exercising muscles and thereby boost performance, as well as recovery.
While it is true that L-arginine supplementation mat be beneficial for various clinical populations (see below), studies in healthy adults have not unequivocally supported the marketing hype surrounding arginine supplementation and nitric oxide boosters [1, 5, 6]. Here’s why…
In this vid, I discuss the popular “Testosterone booster” supplement D-Aspartic Acid (DAA) and update my opinions of this general category of supplements. Note the added study below recently published that found at higher doses, it actually lowered testosterone.
Study mentioned in the vid:
D-Aspartic acid supplementation combined with 28 days of heavy resistance training has no effect on body composition, muscle strength, and serum hormones associated with the hypothalamo-pituitary-gonadal axis in resistance-trained men
PAGE UPDATE: 2015 study and additional comments:
The criticism of some to prior studies was that it was possible higher doses were needed to impact T levels in younger resistance trained men. This study just out below found higher doses actually decreased testosterone! And the study was done on the appropriate population, resistance trained men, although they didn’t test the impact on TT and FT on strength or LBM as the prior study above did. The two studies combined however, do not paint a good picture for DAA in my view. This only lowers, my already low opinion of “T boosters” as a category of supplements…
Three and six grams supplementation of d-aspartic acid in resistance trained men
Geoffrey W Melville*, Jason C Siegler and Paul WM Marshall
Journal of the International Society of Sports Nutrition 2015, 12:15
Although abundant research has investigated the hormonal effects of d-aspartic acid in rat models, to date there is limited research on humans. Previous research has demonstrated increased total testosterone levels in sedentary men and no significant changes in hormonal levels in resistance trained men. It was hypothesised that a higher dosage may be required for experienced lifters, thus this study investigated the effects of two different dosages of d-aspartic acid on basal hormonal levels in resistance trained men and explored responsiveness to d-aspartic acid based on initial testosterone levels.
Twenty-four males, with a minimum of two years’ experience in resistance training, (age, 24.5 ± 3.2 y; training experience, 3.4 ± 1.4 y; height, 178.5 ± 6.5 cm; weight, 84.7 ± 7.2 kg; bench press 1-RM, 105.3 ± 15.2 kg) were randomised into one of three groups: 6 g.d−1 plain flour (D0); 3 g.d−1 of d-aspartic acid (D3); and 6 g.d−1 of d-aspartic acid (D6). Participants performed a two-week washout period, training four days per week. This continued through the experimental period (14 days), with participants consuming the supplement in the morning. Serum was analysed for levels of testosterone, estradiol, sex hormone binding globulin, albumin and free testosterone was determined by calculation.
D-aspartic acid supplementation revealed no main effect for group in: estradiol; sex-hormone-binding-globulin; and albumin. Total testosterone was significantly reduced in D6 (P = 0.03). Analysis of free testosterone showed that D6 was significantly reduced as compared to D0 (P = 0.005), but not significantly different to D3. Analysis did not reveal any significant differences between D3 and D0. No significant correlation between initial total testosterone levels and responsiveness to d-aspartic acid was observed (r = 0.10, P = 0.70).
The present study demonstrated that a daily dose of six grams of d-aspartic acid decreased levels of total testosterone and free testosterone (D6), without any concurrent change in other hormones measured. Three grams of d-aspartic acid had no significant effect on either testosterone markers. It is currently unknown what effect this reduction in testosterone will have on strength and hypertrophy gains.
Full paper HERE
Whether you’re a health/fitness professional or just interested science minded health buff, you know finding objective, balanced, accurate information on health/fitness/nutrition/supplements is both difficult and time consuming. I know many rely on BrinkZone.com for their info, and I’ll be using the ERD as one resource for my information.
It’s a challenge even for yours truly to dig through piles of primary published studies, web sites I trust, and other resources, to distill complex information into useful info for readers, so anything that can help me with that job is a winner in my view.
I received a copy of the ERD and was both impressed with the quality of the content and the layout and graphics, but the process to publication. The ERD is not one person, or a few people sitting around deciding what topic to push to increase sales of some product, but has a legit peer review-like process of editors (some of whom I know personally) to fact check for accuracy and objectivity.*
The ERD distills the latest research for people “in the biz” like me (possibly alerting me to something I need to dig further into) or those looking for an accurate source to rely on as supplement to BrinkZone.com.
A resource that helps me save time, is well written, objective, accurate, puts things in the proper context, and involves a peer review process? I’m in. Highly recommended for anyone looking to save time and energy getting the latest info.
Get more info on the ERD HERE:
* = 5 researchers, 4 editors, and 7 reviewers.