Hi guys and thanks for logging into my first post as part of the BrinkZone. It’s an honor to be involved in such an active and voraciously inquisitive online community dedicated to the real application of nutrition science.
As many of you know I have been deeply involved in research of carnosine and its functions in skeletal muscle. However, recently I was contacted by a write from the Times newspaper (UK) who were conducting research into the medical nutrition, or Mediceuticals as some are defining it. My current work involves patients with genetic conditions leading them to develop extremely high lactate levels inside muscle tissue and associated acidosis (low pH) (Muscle myopathies and cytopathies). Acidosis is related to the fatigue you feel at the end of very high intensity exercise, or at the end of high rep calf rises. However, in the patients I look at the level of acidosis is at levels found during high intensity exercise when they at rest. In real terms this can mean just lifting a tin of beans up can be a real effort.
Since the 1990’s and pioneering work by Dr Mark Dunnett in the field of carnosine metabolism and beta-alanine supplementation it is clear that we can help maintain lower levels of intracellular acidosis in muscle tissue. The future of beta-alanine may next follow the path of creatine as a Mediceutical offering application in the treatment or symptom relief in brain and muscle diseases. In patents suffering from intracellular acidosis and or low muscle carnosine levels (as in old age) beta-alanine supplementation may be a novel therapeutic.
*Beta-Alanine update: Just as a note of interest in a recent publication in the Journal “Amino Acids” researcher have shown that DHA (An Omega-3 fatty acid) reduced concentrations of carnosine in skeletal muscle in an animal study. Although this is an animal trial it maybe worthy avoiding fish oil products at the same time as supplementing with beta-alanine. I would recommend an early morning beta-alanine does and pre-bed time fish oil if you must take both. Other wise cycle beta-alanine 4 weeks on (no supplemental fish oils) 4 weeks off (back on the fish oils).
Li P, Kim SW, Li X, Datta S, Pond WG, Wu G.Dietary supplementation with cholesterol and docosahexaenoic acid affects concentrations of amino acids in tissues of young pigs. Amino Acids. 2008 Oct 30.