Yet another potential benefit of creatine may be improving the effects of SSRIs. There’s many potential health benefits of creatine – for both brain and body – people are unaware of and can read up on via an article I wrote in Life Extension Magazine HERE and here on BrinkZone from vids, articles, free report.
Now, it’s possible, it only works on women and or, only works with this particular SSRI and or only works with MDD. However, knowing that creatine improves brain metabolism in general and has other neuro-protective effects (see recent article linked for more information on that), it’s very unlikely it’s limited to women and or this particular SSRI in my opinion, but one should keep those possible limitation i mind until data shows otherwise. Good science dictates I make sure you’re at least aware of that possible limitation until additional studies done.
I have said this before, and I’ll say it again: Creatine (as monohydrate!) is one of the few supplements I would take and recommended if I didn’t exercise at all.
BTW: The dose of creatine was 3 g/day for the first week and 5 g/day for another 7 weeks.
A Randomized, Double-Blind Placebo-Controlled Trial of Oral Creatine Monohydrate Augmentation for Enhanced Response to a Selective Serotonin Reuptake Inhibitor in Women With Major Depressive Disorder