In this vid I give quick look at some technologies that greatly enhance solubility of compounds known for their poor solubility. Such a technology applied to various supplements could greatly improve their bioavailability. The link in the vid also takes you to another vid and article with additional info on the topic BTW.
EDITORS NOTE: I (Will) recently did a video on ARA which discusses a recent study that found ARA had positive effects on strength and muscle mass readers will want to check out. The results of this study will be covered HERE and in a future article by Monica. This excellent article below by Monica discusses the safety of ARA supplements and possible health benefits that set the record straight on this fatty acid…
In part 1 I outlined the background to the “ARA is bad” theory, and presented studies that have refuted this notion. Part 1 also explains the importance of distinguishing the different omega-6 fatty acids, LA and ARA, and describes the bell-shaped relationship between ARA and EPA + DHA in cell membranes.
In this part you will learn about safety aspects and potential health benefits (!) of ARA supplementation…
Safety and Health Effects of ARA supplementation
With the bad reputation that ARA has, let’s start by looking at safety data. On a typical modern diet (that includes meat, eggs and fish) the average intake of ARA is approximately 100–200 mg ARA per day.[1-5] Several studies have investigated safety aspects of ARA supplementation in different populations.
When healthy volunteers were given over 7 times the usual intake of ARA (i.e. 1500 to 1700 g ARA per day, compared to usual intake of 200 mg ARA per day) in a 7 week controlled feeding study, no effects on platelet aggregation, bleeding times, the balance of vasoactive metabolites, serum lipid levels, or immune response were observed.[6-10] Likewise, in a recent study on healthy men aged 26-60 years, supplementation with 840 mg ARA per day for 4 weeks had no effect on any metabolic parameter or platelet function.
A study in healthy Japanese men and women aged 55-70 investigated whether ARA supplementation affects clinical parameters involved in cardiovascular, inflammatory, and allergic diseases. Subjects were supplemented with ARA-enriched oil (240 or 720 mg ARA per day) or placebo for 4 weeks, followed by a 4-week washout period. The fatty acid contents of plasma phospholipids, clinical parameters, and AA metabolites were determined at baseline, 2, 4, and 8 weeks. It was found that ARA content in plasma phospholipids in the ARA supplemented groups increased dose-dependently and was almost the same at 2 weeks and at 4 weeks. The elevated ARA content decreased to nearly baseline during a 4-week washout period. Contrary to expectations, during the supplementation and washout periods, no changes were observed in plasma phospholipid EPA and DHA content. There were no changes in clinical blood parameters related to cardiovascular, inflammatory and allergic diseases.
The Journal Of Special Operations Medicine (JSOM) covers a wide range of topics focused on special operations forces (SOF). Topics range from medical procedures and other medical based focus (diseases, etc) SOF can face and need medical treatment for. JSOM also covers topics such as training and injury prevention, and even topics such as nutritional supplements that may benefit SOF. For example, JSOM recently published a review of the importance of vitamin D for soldiers.
So, having a personal and professional interest in the topic, it should not be a big surprise I read this journal. Recently Dr. Kyle Hoedebecke and yours truly had an LTE published in JSOM. This short paper was in response to a review paper titled “Operational stressors on physical performance in special operators and countermeasures to improve performance: a review of the literature.” by O’Hara R, Henry A, Serres J, Russell D, Locke R.
In this review the authors concluded that “The rigors of both physical training and prolonged deployments without adequate rest and food intake can compromise physical performance.” After doing a literature search, they concluded that “Specific countermeasures for these known decrements are lacking in the scientific literature.”
Dr. Hoedebecke and I responded that there were published studies that demonstrate a number of nutritional supplements may counteract some of the decrements of training and combat specific to special operations forces (SOF) and other military personnel, and we covered a small sample of nutritional supplements that can directly assist SOF and other military personnel. This is the citation and abstract from what we submitted and was published in JSOM as response:
Hoedebecke K, Brink W. Operational stressors on physical performance in special operators and countermeasures to improve performance: a review of the literature. J Spec Oper Med. 2014 Summer;14(2):84-5.
In the article “Operational Stressors on Physical Performance in Special Operators and Countermeasures to Improve Performance: A Review of the Literature,” O’Hara and colleagues* performed a literature search for “specific countermeasures to reduce or prevent significant decrements in physical performance and reduce musculoskeletal injuries” with the conclusion that “specific countermeasures for these known decrements are lacking in the scientific literature.” This deduction, however, proves inaccurate as evidence within the military community does exist and, unfortunately, has been undervalued. Provided here are only a few examples of present Special Operations Force (SOF)-relevant supplement research.
NOTE: If you’d like to read the full paper by O’Hara R, Henry A, Serres J, Russell D, Locke R. and the response to their paper by Dr. Hoedebecke and myself, JSOM does give a 3 day free membership where you can read back issues, full papers, etc. If interested, go HERE for your free 3 day membership so you can read the above papers as well as others you may find interesting.
Below is a side bar from a lengthy article I recently wrote on the latest studies covering the many potential benefits of creatine. This short side bar covers the possible contraindications of creatine
Are there any contraindications Of Creatine Monohydrate?
Hundreds of studies to date have shown that creatine monohydrate is an amazingly non-toxic and safe supplement with numerous benefits. Further studies directly examining possible side effects, both prospective and long-term retrospective (up to five years), have failed to find any serious side effects of creatine supplementation (65-69) on various markers studied, such as renal function, hepatic function, and others. So are there contraindications of creatine monohydrate?
Although creatine monohydrate is clearly safe for healthy people with a very low side-effects profile using up to 10 grams per day, are there specific groups who should not use it?
Again, the data suggest very few actual contraindications. The only people who should avoid creatine supplements are those with a history of renal disease and/or those taking nephrotoxic (poisonous to the kidneys) medications. There’s been a handful of case reports that show very high doses of creatine (and the reports were not always clear as to what form of creatine was used) were associated with kidney dysfunction.(70) Typical for such a simple case report, it’s unclear what other medications were involved or pre-existing medical condition existed.
However tenuous the connection between high-dose creatine monohydrate and pre-existing kidney dysfunction, it’s prudent to advise people with a history of renal disease and/or those taking nephrotoxic medications to avoid creatine supplementation until more data exists examining that connection. As creatine monohydrate supplementation may cause a transient increase in creatinine levels in some individuals, it may act as a false indicator of renal dysfunction.
Full Article HERE
EDITORS NOTE: I (Will) recently did a video on ARA which discusses a recent study that found ARA had positive effects on strength and muscle mass readers will want to check out. The results of this study will be covered in a future article by Monica when the study is published. This excellent article below by Monica discusses the long held belief this fatty acid is a negative for health and well being. As usual, the truth turns out to be more complex and a read of this article will cover the studies to demonstrate that. Part II of this article can be found HERE.
It is well known that the typical American diet provides too little omega-3 and too much omega-6, and thus has an elevated omega-6/omega-3 ratio. In turn, an elevated omega-6/omega-3 ratio has been linked to a number of common chronic diseases, notably cardiovascular diseases, inflammatory diseases, cancer, and certain psychiatric diseases such as depression.[1-3] The omega-6 fatty acid that has been vilified and blamed to give rise to these detrimental health outcomes is arachidonic acid (ARA).
However, a deeper look at the research data reveals that the association between omega-6 fats, especially ARA, with detrimental health outcomes isn’t as clear-cut as previously thought. Prominent lipid researchers are even questioning the value of the conceptually entrenched omega-6/omega-3 ratio. And there are indications that ARA, previously thought to be the omega-6 villain, actually may confer health benefits and even increase muscle mass and strength when combined with resistance training…in this 3-part series you will find out about it all…
Yes, literally, and could save other children from a lifetime of ill health easily avoided. Genetic disorders effect millions of children, and there’s 29 currently screened for by simple blood test, but not the one this baby and others suffer from. Some children have been mistakenly diagnosed with Cerebral Palsy (and likely other disorders) when in fact it was an easily treatable disorder known as GAMT deficiency or simply “creatine deficiency disorder.” GAMT deficiency, which can be tested for easily, has some researchers pushing for newborn screening that would use the same blood test that screens for 29 recommended disorders. Without early intervention, brain damage can be permanent, so it must be caught early.
This recent story really brings home how this inexpensive non-toxic nutritional supplement could be a life saver for children with this easily testable genetic disorder:
“Estrogen blocker” supplements, do they really work? If so, should people – men in particular – use them? I answer that question in this vid and cover the facts on these supplements as few others can or will…BTW, most of more popular ingredients used in OTC estrogen blocker/anti estrogen supplements used on the market, are covered in detail in my BBR program and SSB book if you want details beyond what this vid covers, either of which can be found in the “Recommended Stuff” section of the site.
What are the facts on this “new” supplement, HMB, or beta-hydroxy-beta-methylbutyrate ? In this vid, you’ll learn the facts on this supplement and know the reality from marketing BS.
NOTE: Study mentioned in this vid (Eur J Appl Physiol. 2014 Mar 6. The effects of 12 weeks of beta-hydroxy-beta-methylbutyrate free acid supplementation on muscle mass, strength, and power in resistance-trained individuals: a randomized, double-blind, placebo-controlled study) used 3g of of HMB in a free acid form (HMB-FA) — the free form of HMB which may have a superior bioavailability over calcium bound HMB. However, vast majority of studies used calcium bound HMB and it’s unclear if the form used in this study was an essential factor to the results. To date, no studies have compared the two forms head to head in terms of effects on body comp, strength, etc.
Is garcinia cambogia (HCA) a legit weight loss agent? Is it safe? What dose is needed? Learn the FACTS in this video!
“You are what you eat” is an old expression your grandmother’s grandmother probably used, but it’s not actually correct technically speaking. Putting on my nerd hat to be a stickler for the details, it’s more accurate to say “you are what you absorb.” Grandma’s sage advice does a good job of illustrating that what we ingest is obviously essential to our health, but what we ingest that actually gets absorbed and utilized by the body is the crux of the issue truth be told.
The piles of studies that have been growing in recent years showing all manner of potential benefits of various nutrients has been very encouraging. We are experiencing an exciting time in nutritional science where new compounds are being discovered – and tested for their potential benefits – almost daily. Compounds that may help prevent cancer, improve immunity, improve weight loss, improve brain function, or improve athletic performance, to name just the tip of the iceberg of where science is currently looking to isolate and test various nutrients for their bio active properties.
How the process works:
Once a compound is discovered, it tends to get isolated, and then tested in either animal models and or in vitro (test tube) to test what positive or negative properties may exist as well as elucidate how they work. That is, understand not just what system they may impact (such as increase an animal’s ability to resist cancer causing chemicals for example) but also examine the isolated compounds’ “mechanism of action” which shows how it achieves the effect. How does that work? Let’s say some spice has been used for generations to reduce infections or improve immunity. Scientists might then feed, or inject, large amounts to lab animals (e.g., mice, rats, rabbits, etc.) and see if it does indeed have activity; perhaps testing how that spice reduces the size of tumors when the mice are exposed to known carcinogens, or bacteria known to cause infections and so forth. If that spice shows biological activity, scientists will often look deeper into that spice to see which specific constituent(s) in the spice are having the “active” compounds, and once found, will concentrate and isolate that active compound and further tests on animals, or humans, or in vitro (test tube) will continue. Foods and spices for example, are highly complex and can have hundreds or even thousands of biologically active compounds in them.