Levels of creatine, organic contaminants and heavy metals in creatine dietary supplements
Food Chemistry. Volume 126, Issue 3, 1 June 2011, Pages 1232–1238


High performance liquid chromatography (HPLC) has been optimised for the analysis of the creatine content and possible organic contaminants in 33 samples of creatine supplements from the market. Creatinine resulted to be the major organic contaminant (44% of the samples over 100 mg/kg). About 15% of the samples had dihydro-1,3,5-triazine concentrations exceeding the detection limit of 4.5 mg/kg (maximum 8.0 mg/kg) and a dicyandiamide concentration over 50 mg/kg, while none of the samples were contaminated with thiourea. The heavy metals (arsenic, cadmium, mercury and lead) content was also assessed by means of inductively coupled plasma mass spectrometry (ICP-MS). Only mercury was present in detectable amounts (at levels lower than 1 mg/kg).


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Research highlights

• A survey on quality of creatine supplements commercialised in Italy has been carried out.
• Creatinine resulted to be the major organic contaminant (44% of the samples over 100 mg/kg).
• 50% of the products exceeded the maximum level recommended by EFSA for organic contaminants.
• Among heavy metals, only mercury was present in detectable amounts (<1 mg/kg)

Full Paper, which is not free, is HERE

What’s In Your Creatine Part I HERE and part II HERE




Will Brink is the owner of the Brinkzone Blog. Will has over 15 years experience as a respected author, columnist and consultant, to the supplement, fitness, bodybuilding, and weight loss industry and has been extensively published. Will graduated from Harvard University with a concentration in the natural sciences, and is a consultant to major supplement, dairy, and pharmaceutical companies.


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