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Risk factors and chronic diseases often get more attention among the middle-age and elderly population. And rightly so, since that’s when the manifestations of chronic diseases start to show up, and when people get reminded about their chronological age.  An integral component of successful aging (also known as healthy aging) is the freedom of physical disabilities and debilitating chronic diseases 1-3. While it is true that it is never too late to become health conscious and reap the benefits of a healthy lifestyle 4,5, the fact remains that the sooner we start the better off we will be as we get older. If you are in your 20s or 30s, or have kids, read on…

This is a long article, so here are some jump-to links:

Appearances are deceptive

Risk factor prevalence

Health risk screening

Bottom Line

References

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A life course approach to successful aging

Chronic diseases are the largest threat to a long and vital life. A prevention-oriented life course approach starting in childhood and young adolescence is critical to establishing and maintaining health throughout life 6-8.  And thereby lays the ground for successful aging as we get older 2,9,10.

Attitudes and risk perceptions among young adults

Adolescents and young adults often underestimate the negative consequences of their personal behaviors and habits, and have unrealistic optimism of vulnerability 11-15. This is especially true for heart/cardiovascular disease risk 11,16-19. This “I am young and don’t have to worry” or “it won’t happen to me” attitude, however, can have serious impact on lifestyle choices and future health outcomes.

Denial is putting a large majority of the population at undue high risk. The Heart and Stroke Foundation found that while people are aware of the importance of addressing their risk factors, most have a false sense of security that is cutting their lives short 20. People consistently overestimate their own healthy behaviors:

  • Almost 90% of rate themselves as healthy. The reality is that 9 out of 10 s have at least one risk factor for heart disease and stroke.
  • Only about a third said they are not physically active or don’t eat a minimum of five servings of vegetables and fruit per day. The reality is about half don’t meet the physical activity and healthy eating recommendations.
  • 18% of adults say they are obese. The reality is that almost one quarter – 25% – are obese.

Among people with blood lipid abnormalities, only 35% are aware that they have it 21, and many don’t even know their blood pressure 22. This huge chasm between perception and reality could be fatal.

Appearances are deceptive

The fact that appearances are deceptive is true in many areas in life, and most of us have experienced it first hand in social interactions. However, it is also true when it comes to risk factors for chronic diseases.

While visible risk status, like body fatness, diet and exercise, is a good marker for other non-visible risk factors (like blood pressure, diabetes, respiratory function), they don’t always go together. It has been documented in both the lay and medical arena that even people with no visible risk factors die prematurely, and conversely that sometimes people who show visible risk factors live longer than expected 23. A study that specifically investigated these “anomalous deaths” and “unwarranted survivors” concluded that theses aberrant observations can be explained by the presence or lack of non-visible risk factors 24. While the low visible risk status group in general lived longer than the high visible risk status group, within each group there were notable survival differences. Premature deaths in the low visible risk status group were explained by the presence of non-visible risk factors, and longer than expected survival in the high visible risk status group was due to absence of non-visible risk factors 24.

Therefore, even if your appearance shows a low risk status, it is important that you still keep track of your invisible risk parameters by getting your regular blood work and health checkups.

Risk factor prevalence

Today very few Americans are at low risk for heart disease. Approximately 78% of adults aged 20-80 years alive today in the United States are candidates for at least one prevention activity 25. Over 55% of young adults have at least one cardiovascular disease risk factor, and over 37% reported having two or more 26.

According to the National Center for Health Statistics, half of American adults have one or more of the three major risk factors: dyslipidemia (abnormal amounts of lipids, lipoproteins and sub-fractions in the blood), high blood pressure, or diabetes 27.  The National Center for Health Statistics also estimates that 15% of adults having one of more of these three risk factors but remain undiagnosed and hence untreated 27.  Recent updates show the following prevalence rates 28-30:

68% overweight or obese

59% abstaining from any vigorous activity

34% hypertension (high blood pressure)

32% pediatric obesity or overweight

36% pre-diabetes in adults over 20 years of age; 50% in those over 65 years of age

34% metabolic syndrome

27% undiagnosed diabetes

21.2% tobacco use

11.2% of adults with both pre-hypertension and pre-diabetes

Among young adults aged 18-39 years, only 20% meet low risk criteria, and almost 60% have high levels of at least one risk factor 31. In young adult and middle-aged populations, aged 18 to 59 years, only 5-10% have a low health risk status 32.

If everyone received the activities for which they are eligible, heart attacks and strokes would be reduced by 63% and 31%, respectively 25. Of the specific prevention activities, the greatest benefits to the US population come from controlling pre-diabetes, weight reduction in obese individuals, lowering blood pressure, and improving blood lipids 25.

Thus, there is a widespread failure of people to accept disease risks that aren’t obvious and are asymptomatic 33. This, coupled with the enormously high risk factor prevalence in the general public, provides a good rationale to regularly do health checkups, and to start doing so at an early age 34. The fact that risk factor control in adults and elderly reduces, but doesn’t eliminate disease 35 further underscores the importance of early monitoring, prevention and intervention. What’s especially disturbing is that even doctors often underestimate their patient’s risk and are ignorant of risk factors they feel don’t belong to their special medical area 87-90 .  So put your foot down if your physician gives you a clean bill of health without running any comprehensive labs tests.

Health risk screening

Health risk screening is the practice of regularly doing health check-ups even in the absence of manifest disease or disability.

The high prevalence of pre-diabetes and undiagnosed diabetes is especially alarming since elevated fasting blood glucose levels even within the “normal” range greatly increase the risk for development of full-blown type 2 diabetes 36, stomach cancer 37, and heart attack 38. Fasting blood glucose values in the upper normal range are an important independent predictor of cardiovascular death even in non-diabetic apparently healthy people 39.

A mounting body of evidence shows that high after-meal blood glucose spikes inflict as much or more damage than high fasting blood sugar 40,41. Among individuals with “normal” blood sugar readings, heart attack risk increases by 58% for a 21 mg/dl increase in after-meal blood sugar level 38. Thus, including

2-h after-meal glucose tests improves the predictive ability to identify non-diabetic individuals at increased risk of cardiovascular death 42. The good news is that many interventions that reduce blood sugar also lower insulin 43, LDL 44-46, triglycerides 44,47-50, and CRP (C-reactive protein, see below) 51, obesity 49,50,52,53 and increase HDL 53, and thereby slash the risk of vascular disease 54, cancer 55,56, dementia 57,58 and many other degenerative disorders.

Chronic disease develops and progresses silently for many years before it strikes a clinical manifestation. This is especially true for atherosclerotic diseases such as coronary heart disease, stroke, and peripheral artery disease, which are major health threats. While atherosclerotic complications don’t show up until middle-age or later, the atherosclerotic inducing process begins already in childhood, and has an incubation period of decades and progresses throughout an individual’s lifetime 59-64.

The development of early stages of atherosclerosis in children and adolescents is a function of the same traditional risk factors that affect adults. Worsening of risk factors accelerates the process, and their improvement slows or is even capable of reversing it. The longer the exposure to, and the greater the intensity of the risk factors involved, the higher the atherosclerotic burden will become 64,65.

Significant raised atherosclerotic lesions increase rapidly in prevalence and extent during the 15- to 34-year age span. Therefore, primary prevention of atherosclerosis, in contrast to primary prevention of clinically manifest heart/vascular disease, must begin in childhood or adolescence 66. It was recently found that childhood risk factor measurements obtained at or after 9 years of age are strongly predictive of subclinical atherosclerosis in adulthood 67.

Another study found that dyslipidemia also has consequences during young adulthood. To assess whether non-optimal blood lipid levels during young adulthood cause atherosclerotic changes that persist into middle age, young men and women age 18 to 30 years were followed for 20 years 68. It was found that a whopping 87% had non-optimal baseline levels of LDL cholesterol (over 2.59 mmol/L or over 100 mg/dL), HDL cholesterol (below 1.55 mmol/L or below 60 mg/dL), or triglycerides (over 1.70 mmol/L or over 150 mg/dL) during young adulthood. Coronary calcium (a strong predictor of future coronary heart disease) prevalence 20 years later was 8% in participants who maintained an optimal blood lipid profile, compared to 44% in participants with who did not 68. Both LDL and HDL cholesterol levels were independently associated with coronary calcium, even after participants who were receiving lipid-lowering medications or had clinically abnormal lipid levels were excluded 68. This study shows that even moderate deviations from an optimal blood lipid profile has a significant and long-lasting impact on coronary atherosclerosis in middle-age.

Carotid artery intima-media thickness (CIMT) is a marker of preclinical “silent” atherosclerosis 69, and  cardiovascular risk factors during childhood predicts increased CIMT 20 years later 70-73. A recent study examined whether childhood and adolescent (3-18 years of age) risk factors are associated with CIMT progression independent of current, adulthood risk factors 74. After an extended 27 year follow-up with repeated CIMT measurements, it was found that exposure to risk factors in childhood was associated with increased CIMT progression rate in adulthood 74. The childhood risk score, reflecting the composite load of youth risk exposure, was associated with IMT progression even after taking into account the current risk score. When the effects of individual risk variables were assessed, frequent fruit consumption and high physical activity in childhood remained associated with lower adult CIMT progression 74. These observations indicate that children with risk factors have increased atherosclerosis progression rate in adulthood and support the idea that atherosclerosis prevention by means of life style are effective when initiated in childhood 75.

In contrast to childhood life-style variables, the associations of childhood blood lipid values and fatness with CIMT progression became non-significant when adjusted for current adult risk factor levels. Thus, although a composite childhood risk burden was independently associated with CIMT progression, the effects of these specific risk factors lost their significance after the adjustment for adult values. The greater relative importance of adult lipid levels and obesity when compared with those in childhood is also supported by the observation that favorable changes in lipid profile and obesity status from childhood to adulthood were associated with slower atherosclerosis progression. For example, in subjects with low HDL/LDL cholesterol ratio in childhood, only those with low ratio also in adulthood had increased CIMT progression in adulthood. Similarly, obese youths who became lean adults had slower CIMT progression than persistently obese subjects. These findings suggest that it is not too late to start interventions targeting blood lipids and obesity during transition from youth to adulthood to reduce progression of atherosclerosis.

The strong association between coronary heart disease and unfavorable blood lipid profiles has often overshadowed the effects of the non-lipid risk factors like obesity, and diabetes, impaired glucose tolerance, high blood pressure and smoking. It has even led to questioning the importance of these risk factors in the presence of a favorable lipoprotein profile. In a study that investigated the impact of these non-lipid risk factors in young adults, 15 to 34 years of age, with optimal blood lipid profiles, it was found that all of them caused atherosclerotic lesions despite the presence of optimal blood lipid profiles 76. This finding underscores the need to control all cardiovascular risk factors 76.

Another important non-lipid risk factor is CRP (C-reactive protein), an inflammatory marker that can flag atherosclerosis and impending heart disease 77-79. CRP predicts the progression of carotid atherosclerosis in both the middle-aged and elderly (40-70 year old)80, and in young adults (aged 24 to 43 years) 81. In young adults, CRP has independent association with CIMT progression 81, which provides a rationale to screen CRP levels as well, in addition to traditional lipid risk factors. Recent accumulating evidence is showing that CRP is no longer regarded as merely an indicator of cardiovascular risk, but increasingly considered a direct partaker in the development of atherosclerotic cardiovascular disease 82. Thus, rest assured we will hear more about CRP reducing interventions in the near future.

Bottom line

Even if you think your health is good and you aren’t suffering today, don’t take your current health status for granted. Many invisible risk factors can hide behind the surface. Do you really know what your blood pressure, HDL and fasting blood sugar is? And what about C-reactive protein (CRP), the “new” risk factor which has been shown to be a stronger predictor of cardiovascular events than the infamous LDL (the “bad” cholesterol) 83? Most people don’t know their invisible risk factors; make sure not to be one of them. Regular health screening and follow-ups are a prerequisite for successful aging.

While it is true that some of the negative effects of early life influences can effectively be overcome by current healthier behaviors 84, the way one arrives at middle age sets the stage for the years to follow 85. And how well we fare at middle age is in turn determined by how we lived in young adulthood, and even influenced by our childhood years.

Here’s the rationale for regular health screening even in apparently healthy young individuals and children over 9 years:

- The high prevalence of risk factors, both visible and invisible.

- The largest killer, cardiovascular diseases, start to develop silently early in life.

- Most of us have a tendency to greatly underestimate our own health risks.

- Physiological processes that lay the ground for chronic diseases, especially cardiovascular diseases, start early in life. The health status of children aged 9 years or older will have impact on later life health outcomes.

The sooner risk factors are detected and treated, and the more years of our lives that we spend engaging in healthy lifestyle behaviors, the greater our odds for aging successfully and staying vital up to old age. Don’t jeopardize the quality and length of your life by living in denial; take action now and schedule your blood work exam to track your invisible risk factors. See it as an investment in your and your family’s health and happiness. While there will always be exceptions, overall there is truth in  ”the older you get, the healthier you have been” 86. Take action now to gain control of your aging destiny!

About Monica Mollica > www.trainergize.com

Monica Mollica has a Bachelor’s and Master’s degree in Nutrition from the University of Stockholm, Sweden, and is an ISSA Certified Personal Trainer. She works a dietary consultant, health journalist and writer for www.BrinkZone.com, and is also a web designer and videographer.

Monica has admired and been fascinated by muscular and sculptured strong athletic bodies since childhood, and discovered bodybuilding as an young teenager. Realizing the importance of nutrition for maximal results in the gym, she went for a BSc and MSc with a major in Nutrition at the University.

During her years at the University she was a regular contributor to the Swedish bodybuilding magazine BODY, and she has published the book (in Swedish) “Functional Foods for Health and Energy Balance”, and authored several book chapters in Swedish publications.

It was her insatiable thirst for knowledge and scientific research in the area of bodybuilding and health that brought her to the US. She has completed one semester at the PhD-program “Exercise, Nutrition and Preventive Health” at Baylor University Texas, at the department of Health Human Performance and Recreation, and worked as an ISSA certified personal trainer. Today, Monica is sharing her solid experience by doing dietary consultations and writing about topics related to health, fitness, bodybuilding, anti-aging and longevity.


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Monica Mollica holds a Master Degree in Nutrition from the University of Stockholm and Karolinska Institue, Sweden. She has also done PhD level course work at renowned Baylor University, TX.

 

Monica is a medical writer, body transformation coach, diet/supplement consultant, and a regular contributor to www.BrinkZone.com.

 

Check out Monica's website www.trainergize.com

 

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