Viagra and muscle? Does Viagra, or Cialis help build muscle? Athletes from body builders to football players to mountain climbers use these PDE inhibitor drugs. Why? In this vid I cover the facts behind their use.
Sildenafil Increases Muscle Protein Synthesis and Reduces Muscle Fatigue
Clinical and Translational Science
Volume 6, Issue 6, pages 463–468, December 2013
Reductions in skeletal muscle function occur during the course of healthy aging as well as with bed rest or diverse diseases such as cancer, muscular dystrophy, and heart failure. However, there are no accepted pharmacologic therapies to improve impaired skeletal muscle function. Nitric oxide may influence skeletal muscle function through effects on excitation-contraction coupling, myofibrillar function, perfusion, and metabolism. Here we show that augmentation of nitric oxide-cyclic guanosine monophosphate signaling by short-term daily administration of the phosphodiesterase 5 inhibitor sildenafil increases protein synthesis, alters protein expression and nitrosylation, and reduces fatigue in human skeletal muscle. These findings suggest that phosphodiesterase 5 inhibitors represent viable pharmacologic interventions to improve muscle function.